A small number of people who use sertraline have reported severe chest pain after taking the medication. It’s important to point out that this side effect is very rare. Although it is generally viewed as safe and effective, Zoloft, like any medication, can cause side effects. Most mild Zoloft side effects will dissipate within a few weeks as your body adjusts to the medication. Yes, Zoloft can interact with other medications, potentially increasing the risk of side effects, including chest pain. It’s crucial to inform your doctor about all medications, supplements, and herbal remedies you are taking. Sertraline can cause serotonin syndrome when it is taken alone or with other medicines that affect serotonin. This condition can be life-threatening. If it’s not working as well as it could, sertraline could build up in your body and cause additional side effects. Because of this, your prescriber will likely start with a lower dose of sertraline if you have liver problems. Check with your doctor right away if you have chest pain or discomfort, fainting, irregular or slow heart rate, or trouble breathing. These may be symptoms of heart rhythm problems, including QT prolongation and torsades de pointes. Zoloft can heighten your anxiety when you start out and can trigger chest pains that come and go. They also said to come back if I felt them and got worried, better to get checked and be wrong than to miss something. While rare, Zoloft can cause chest pain. Learn about potential heart-related risks, how to differentiate it from anxiety, and when to seek immediate medical attention for chest pain. What are the more common side effects of Zoloft? Zoloft can cause certain side effects, some more common than others. These side effects may be temporary, lasting a few days to weeks. Check with your doctor right away if you have chest pain or discomfort, fainting, irregular or slow heart rate, or trouble breathing. These may be symptoms of heart rhythm problems, including QT prolongation and torsades de pointes.